Antiangiogenesis signals by endostatin
نویسندگان
چکیده
منابع مشابه
Antiangiogenesis signals by endostatin.
Endostatin is a potent endogenous angiogenesis inhibitor that induces regression of tumors in mice. Neither an extracellular receptor for endostatin nor intracellular signals that result in the regression of tumor vascular beds have been identified. We demonstrate that endostatin, but not angiostatin, at comparable concentrations to those used in in vivo animal trials, rapidly down-regulates ma...
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Tumor growth depends on its capacity to induce formation of new blood vessels [1]. Endostatin, a 20-kDa C-terminal fragment of collagen XVIII, is a potent antiangiogenic agent, fully inhibiting tumor growth in mouse models [2]. Since 2000, endostatin has been tested in patients as an experimental therapeutic agent. Results of clinical trials show that tumor size is not reduced under endostatin ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2001
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fsb2fj991083com